Deleting the profile will happen outside of Outlook, since you can’t open it – something many “guides” out there happen to forget. With that being said, here is the tutorial for deleting a profile when you are stuck on “loading profiles”. In case you are not sure, you might want to find another solution because your mails might be gone permanently. When the suspected “corrupt” profile is a M365 profile or uses IMAP, you can safely follow this tutorial as recreating the profile will just make Outlook load all your e-mails, folders and wht else for you from the servers. If you run into this problem you have to ask yourself one question first before following this tutorial: Can you recover the mails and content easily? Personally, I experienced this problem when someone botched an Office365 migration, making a connected profile lose its mind. One possible reason for this is that there is a serious issue with your account.
No matter what you do, Outlook simply won’t open. When Outlook starts, it is possible that it hangs on “Loading Profiles”. But it’s mostly a tutorial to help you solve a problem you might run into.
But this is not a post to complain about Outlook. Outlook is a tool I use because it’s the best tool for the job while I still think it’s pretty bad. I’ve always had a hate-love-hate relationship with Outlook.